Uses differential ultracentrifugation combined with quantitative proteomics (dynamic organellar maps) to show that structurally diverse NLRP3 activators uniformly displace the endocytic AP2 complex from the plasma membrane, identifying this disruption as a common surveillance checkpoint linking impaired GPCR signaling to inflammasome activation and pyroptosis.

Compares passive samplers (POCIS and Chemcatcher) with grab sampling techniques (SBSE and SPE) for pesticide monitoring in Australian surface waters, screening 230 pesticides across three sites with distinct land uses and evaluating suitability for citizen science applications.

Investigates proteome dynamics across three fermentation stages in sequential cultures of S. bacillaris FRI751 and S. cerevisiae EC1118, revealing that S. bacillaris significantly modulates S. cerevisiae's proteome and accelerates reduction of cell wall enzymes relevant to wine quality.

Uses cell surface proximity biotinylation coupled with mass spectrometry to map the PD-L1 interactome in melanoma cells, identifying tetraspanin TSPAN4 as a novel negative regulator that promotes PD-L1 degradation and restricts its lateral mobility at the plasma membrane.

Combines RNA-seq and Ribo-seq across ten developmental stages of maize anthers to map translational dynamics, identifying functional ORFs in 3′ UTRs linked to male sterility — including the APV1 locus — and revealing reduced photosynthetic activity in anther tissue.

Analyzes associations between urinary genistein, daidzein, and equol concentrations and semen parameters in 157 Japanese men seeking fertility treatment, finding negative associations between isoflavone levels and sperm count and concentration measured by LC-MS/MS.

Develops novel magnetic bead enrichment resins for large-scale cysteine thiol site profiling, identifying over 40,000 thiol sites across five tissues in a high-fat diet mouse model of obesity using DIA-based label-free quantification.

Employs TurboID-based proximity labeling to map the in vivo interactome of the photoprotective PsbS protein in Arabidopsis chloroplasts, identifying both known partners (Lhcb1.3, Lhcb4.2) and novel binding proteins including TLP18.3 and ZEP, revealing new insights into non-photochemical quenching regulation.

Reports the first gold-based PROTAC, featuring a Au(III) covalent warhead linked to a cereblon-recruiting moiety, which selectively degrades the oncogenic kinase MERTK and TXNL1 in leukemia cells, validated by proteasome inhibition rescue.

Identifies [(NHC1)2Au]Br as a promising candidate against platinum-resistant ovarian cancer by inhibiting oxidative phosphorylation and forcing a metabolic collapse in cisplatin-resistant cells already reliant on maximal glycolysis.