Develops novel magnetic bead enrichment resins for large-scale cysteine thiol site profiling, identifying over 40,000 thiol sites across five tissues in a high-fat diet mouse model of obesity using DIA-based label-free quantification.

Employs TurboID-based proximity labeling to map the in vivo interactome of the photoprotective PsbS protein in Arabidopsis chloroplasts, identifying both known partners (Lhcb1.3, Lhcb4.2) and novel binding proteins including TLP18.3 and ZEP, revealing new insights into non-photochemical quenching regulation.

Reports the first gold-based PROTAC, featuring a Au(III) covalent warhead linked to a cereblon-recruiting moiety, which selectively degrades the oncogenic kinase MERTK and TXNL1 in leukemia cells, validated by proteasome inhibition rescue.

Identifies [(NHC1)2Au]Br as a promising candidate against platinum-resistant ovarian cancer by inhibiting oxidative phosphorylation and forcing a metabolic collapse in cisplatin-resistant cells already reliant on maximal glycolysis.

Uses proximity-dependent protein labelling in transgenic barley to identify host interactomes of five AVRA effectors, discovering that AVRA13 specifically targets the receptor kinase HvSRF3 to disrupt iron homeostasis and promote fungal virulence.

Discovers NISM, a 36 amino acid microprotein encoded in the HDAC5 5′-UTR, that regulates nucleolar formation and ribosomal RNA synthesis by promoting liquid-liquid phase separation of the RNA helicase DHX9.

Reveals that oncogene-driven SUMOylation suppresses HLA class-I antigen presentation by impairing immunoproteasome activity and TAP1 transport, and shows that pharmacological SUMO inhibition unmasks a targetable neoepitope repertoire to enhance cancer immunotherapy.

Identifies a mechanism by which reactive astrocytes drive neurodegeneration in Parkinson's disease and Lewy body dementia by releasing lysosomal contents that acidify the extracellular environment and activate neuronal ASIC1a channels.

Experimentally validates HLA ligand presentation of 176 predicted neoepitope-HLA combinations, finding only 22% are successfully presented, with significant implications for cancer vaccine design and immune evasion studies.

Comparative phosphoproteomic study examining abscisic acid signaling across three major crop species to identify conserved and divergent phosphorylation networks involved in drought stress responses.