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Expert application notes, method guides, and technical insights powering your SPE and proteomics research.
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How to Desalt Peptides for LC-MS/MS Analysis Using C18 StageTips: A Step-by-Step Protocol
A complete, practical guide to peptide desalting with Empore™ C18 StageTips — from sample acidification through elution — with troubleshooting tips and best practices for maximizing peptide recovery. Authors: CDS Empore™ Technical Team Introduction Peptide desalting is one of the most critical — and most underappreciated — steps in any bottom-up proteomics workflow. After enzymatic digestion, your peptide sample typically contains salts, buffers, urea, detergents, or other re
6 min read
EPA Method 8270E: Extract 125 Semi-Volatile Organic Compounds from Water Using the Empore™ 8270 Disk
Authors: Xiaohui Zhang, Guotao Lu, Michael Apsokardu A validated EPA Method 8270E workflow using the CDS Empore™ 8270 Disk extracts 125 semi-volatile organic compounds (SVOCs) from 250 mL water samples spiked at 20 µg/L. Most compounds achieved recovery greater than 75% with RSD below 15% (n=3), making the workflow a versatile, regulator-compliant option for wastewater detection laboratories operating under EPA 8270E and SW-846 Method 3535. Study at a Glance Introduction: The
8 min read
Analysis of Polynuclear Aromatic Hydrocarbons Using US EPA Quick Turnaround Method (QTM) with the Empore™ C18 SPE Disk
Authors: Guotao Lu Study summary: A validated solid-phase extraction (SPE) workflow using the CDS Empore™ 47 mm C18 SPE Disk extracts 16 PAHs from 100 mL aqueous samples per the U.S. EPA Quick Turnaround Method (QTM). After methylene chloride elution, anhydrous sodium sulfate drying, and nitrogen concentration to 1.0 mL, PAHs are quantified by GC-FID. Validated in groundwater from hazardous waste sites at two spike levels: 200 ppb (n=6, average RSD 5.9%) and 20 ppb (n=3, aver
9 min read
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