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Blog Library
Expert application notes, method guides, and technical insights powering your SPE and proteomics research.
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How to Desalt Peptides for LC-MS/MS Analysis Using C18 StageTips: A Step-by-Step Protocol
A complete, practical guide to peptide desalting with Empore™ C18 StageTips — from sample acidification through elution — with troubleshooting tips and best practices for maximizing peptide recovery. Authors: CDS Empore™ Technical Team Introduction Peptide desalting is one of the most critical — and most underappreciated — steps in any bottom-up proteomics workflow. After enzymatic digestion, your peptide sample typically contains salts, buffers, urea, detergents, or other re
6 min read
EPA Method 8270E: Extract 125 Semi-Volatile Organic Compounds from Water Using the Empore™ 8270 Disk
Authors: Xiaohui Zhang, Guotao Lu, Michael Apsokardu A validated EPA Method 8270E workflow using the CDS Empore™ 8270 Disk extracts 125 semi-volatile organic compounds (SVOCs) from 250 mL water samples spiked at 20 µg/L. Most compounds achieved recovery greater than 75% with RSD below 15% (n=3), making the workflow a versatile, regulator-compliant option for wastewater detection laboratories operating under EPA 8270E and SW-846 Method 3535. Study at a Glance Introduction: The
8 min read
Environmental
Analysis of Polynuclear Aromatic Hydrocarbons Using US EPA Quick Turnaround Method (QTM) with the Empore™ C18 SPE Disk
Authors: Guotao Lu Study summary: A validated solid-phase extraction (SPE) workflow using the CDS Empore™ 47 mm C18 SPE Disk extracts 16 PAHs from 100 mL aqueous samples per the U.S. EPA Quick Turnaround Method (QTM). After methylene chloride elution, anhydrous sodium sulfate drying, and nitrogen concentration to 1.0 mL, PAHs are quantified by GC-FID. Validated in groundwater from hazardous waste sites at two spike levels: 200 ppb (n=6, average RSD 5.9%) and 20 ppb (n=3, aver
9 min read
Rapid Strontium-90 Water Analysis Using the Empore™ Strontium Rad Disk
Authors: Jianwen Hu, Xiaohui Zhang, Guotao Lu Study summary: A rapid solid-phase extraction (SPE) method for Strontium-90 water analysis has been validated using the Empore™ Strontium Rad Disk and a low-background α/β counter. After acidifying a 1.00 L water sample and passing it through the 47 mm Strontium SPE disk, the disk is counted directly for 60 minutes with no additional sample preparation. The method achieves a minimum detectable concentration of 0.019 Bq/L with a to
9 min read
EPA Method 1613B: Dioxin & Furan Analysis in Industrial Wastewater Using the Empore™ C18 SPE Disk
Authors: Guotao Lu Study summary: A validated EPA Method 1613 Rev. B workflow using the Empore™ C18 SPE Disk extracts 16 toxic 2,3,7,8-substituted polychlorinated dibenzo-p-dioxins (PCDDs) and dibenzofurans (PCDFs) from 1 L industrial wastewater samples at pH 2. Across four matrices — POTW final effluent, petroleum refinery API separator effluent, refinery final treatment effluent, and river water — all 16 native compounds fell within the EPA-required 75%–125% acceptance wind
11 min read
EPA Method 527.1: Extract Pesticides and Flame Retardants from Drinking Water Using Empore™ SDB-XC Disk and EZ-Trace
Authors: Xiaohui Zhang, Michael Apsokardu Study summary: A validated EPA Method 527.1 workflow using the Empore™ SDB-XC SPE Disk with the EZ-Trace SPE Workstation extracts 26 pesticides and flame retardants (including pyrethroids, organophosphates, and polybrominated diphenyl ethers) from 1 L drinking water samples. With 1.0 and 2.0 µg/L spike levels (n=4), 92% of analytes fell within EPA's 70-130% acceptable recovery range with average recovery of 102.7% (RSD 15.8%) and 102.
7 min read
EPA Method 525.2: Extract SVOCs from Drinking Water Using the Empore™ C18 SPE Disk
Authors: Xiaohui Zhang, Guotao Lu Study summary: A validated EPA Method 525.2 workflow using the Empore™ 47 mm C18 SPE Disk extracts 102 semi-volatile organic compounds from 1 L drinking water samples spiked at 2 µg/L. 89 compounds achieved recovery above 85% with average RSD 4.7%, and 98 of 102 compounds fell within the 70%–130% range required by EPA Method 525.2 — making the Empore C18 disk a qualified solution for drinking water monitoring of pesticides, PCBs, phthalates,
8 min read
EPA Method 8270E: Extract 125 Semi-Volatile Organic Compounds from Water Using the Empore™ 8270 Disk
Authors: Xiaohui Zhang, Guotao Lu, Michael Apsokardu A validated EPA Method 8270E workflow using the CDS Empore™ 8270 Disk extracts 125 semi-volatile organic compounds (SVOCs) from 250 mL water samples spiked at 20 µg/L. Most compounds achieved recovery greater than 75% with RSD below 15% (n=3), making the workflow a versatile, regulator-compliant option for wastewater detection laboratories operating under EPA 8270E and SW-846 Method 3535. Study at a Glance Introduction: The
8 min read
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